Pharmaceutical Products

u-47700 u-47700 u-47700 u-47700 cas:82657-23-6 fuf

1.Product Info:



U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s that acts as a selectiveagonist of the μ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor and has around 7.5 x the potency of morphine in animal models.

U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.

U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research.



Analogues:


Spiradoline

U-69,593

U-77891







Product name

U-47700
CAS

82657-23-6
IUPAC name

3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide
Formula

C16H22Cl2N2O
Molecular weight

329.27g/mol
Compound purity

99%

Appearance

white powder
Application

For lab research

Storage

Keep in cool and dry place

Package

aluminium alloy bag or according to requirement

Place of origin

Hebei

Type of shipping

EMS, TNT, FEDEX, DHL, UPS

Payment terms

T/T or Western Union or Money Gram or Bitcoin

Delivery time

Within 1-3 days

MOQ

10g

Production capacity

500kg/month





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