U47700 Research Chemical Intermediates 486459-03-4 Safe Opioid Research Chemicals - 01
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U47700 Research Chemical Intermediates 486459-03-4 Safe Opioid Research Chemicals
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1. Quick details
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Means Of Transport: Air | Package: In Foil Bag Or Customized |
Product Name: U47700 | Production Capacity: 500kg/month |
Cas No: 486459-03-4
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Skype: live:sales02_1697
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Port: Hongkong | Application: Chemical Research |
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2. Definitions
U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s?that acts as a selective agonist of the μ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor?and has around 7.5 x the potency of morphine in animal models.
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3.?character
U-47700 is a structural isomer of the earlier opioid AH-7921??and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold.
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Upjohn looked for the key moieties which gave the greatest activity[8] and posted over a dozen patents on related compounds, each optimizing one moiety] until they discovered that U-47700 was the most active.
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U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research.
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4. Pharmacology
U-47700 is selective for the μ-opioid receptor, with various sources claiming 7.5x the potency of morphine.
Opioids exert their effects by binding to and activating the μ-opioid receptor. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the μ-opioid receptor set.
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The way in which opioids structurally mimic these natural endorphins results in their euphoria, pain relief and anxiolytic effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement.
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U-47700 may also be an agonist for the kappa-opioid receptor system. As a result of this, it has become the lead compound of selective kappa-opioid receptor ligands such as U-50488 and U-69,593, which share very similar structures.?Its structure led to other chemists experimenting with it to see if rigid analogues would retain activity. ?Although not used medically, the selective kappa ligands are used in research.
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5. Pictures
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