Pharmaceutical Products

Effective Anti Tumor Inhibitor API Tofacitinib Citrate
(CAS: 540737-29-9)

Chemical Information
Quick Details:
Product Name Tasocitinib
Molecular Formula C16H20N6O.C6H8O7
Molecular Weight 504.49
Storage 3years in -20oC
Targets Abl c-Src
Dosage 30 nM; intraperitoneal injection
Target JAK3 JAK2 JAK1 ROCK2 LCK
IC50 1 nM 20 nM 112 nM 3.4 μM 3.87 μM
Product Name: Tofacitinib Citrate
CAS No.: 540737-29-9
MF: C16H20N6O.C6H8O7
MW: 504.497

Product Description
Tofacitinib (formerly tasocitinib, CP-690550) is a drug being investigated for the treatment of rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection. It is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.

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