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Tetracaine Base HCL Powder - 136-47-0

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CAS: 136-47-0
EINECS: 205-248-5
Assay: 98.0%-101.0%
Standard: USP32
Packing: 1kg/foil bag; 25kg/cardboard drum
MF: C15H25ClN2O2
MW: 300.82
Character: Tetracaine hydrochloride (136-47-0) is white crystal or crystalline powder, odorless, slightly bitter taste, a sense of numbness of tongue. Tetracaine hydrochloride (136-47-0) soluble in water, dissolved in ethanol, insoluble in ether or benzene..
Usage:Tetracaine hydrochloride (CAS NO.136-47-0) is A local anesthetic used topically in opthalmology. Local anesthetic action of Be Proulx Kain strong, 10 times larger than procaine. Toxicity is greater, 10-12 times larger than procaine. Through the mucosa, mainly used for mucosa anesthesia.

Description:

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Applications:

Tetracaine is an Ester Local Anesthetic. The physiologic effect of tetracaine is by means of Local Anesthesia. The chemical classification of tetracaine is Esters.

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