Telmisartan CAS 144701-48-4 for hypertension Treatment (jerryzhang001@chembj.com) - 144701-48-4
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Telmisartan CAS 144701-48-4 for hypertension Treatment
Quick Detail:
Product Name: Telmisartan
Synonyms: TELMISARTAN;PRITOR;MICARDIS;BIBR 277;4& acute;[(1,4& acute;-DIMETHYL-2& acute;-PROPYL[2,6& acute;-BI-1H-BENZIMIDAZOL]-1& acute;-YL)METHYL][1,1& acute;-BIPHENYL]-2-CARBOXYLIC ACID;4& acute;-[(1,4& acute;-DIMETHYL-2& acute;-PROPYL[2,6& acute;-BI-H-BENZIMIDAZOL]-1& acute;-YL)METHYL][1,1& acute;-BIPHENYL]-2-CARBOXYLIC ACID;3-methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl sulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraene.
CAS: 144701-48-4 ;
MF: C33H30N4O2 ;
MW: 514.63 .
Description:
Telmisartan is a novel type of blood pressure lowering drug and is a kind of specific antagonist for the angiotensin II receptor (AT I type) antagonist for the treatment of essential hypertension, replacing the angiotensin II receptor for binding with the AT I receptor subtypes (known action sites of angiotensin II) with high affinity. Telmisartan has no site agonist effect on the AT I receptor and selectively binds with the AT I receptors with a long-lasting binding effect. It has no affinity to other receptors (including AT2 and other less characterized AT receptors). The function of other receptors remains unknown.?
Medical Function:
Since telmisartan resulting in increased levels of angiotensin II, it is also possible to cause excessive stimulating effect on the receptor. Telmisartan does not inhibit human plasma renin, nor block the ion channel. It does not inhibit the angiotensin-converting enzyme II that can alleviate the adverse reaction of the enhanced effect of bradykinin.
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