Tamoxifen, Nolvadex - Active Pharmaceutical Ingredients;Protein Kina
Tamoxifen, Nolvadex For Sale, Most Competitive Price, Fast Delivery, Custom Service, Wholesale Tamoxifen, Nolvadex, Made in China, High Quality Products!, China Nolvadex , Antiestrogen Supplier, Manufacturer.Tamoxifen, Nolvadex
Basic information
CAS: 10540-29-1
MF: C26H29NO
MW: 371.51
EINECS: 234-118-0
Product Categories: Active Pharmaceutical Ingredients;Protein Kinase Inhibitors and Activators;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Aromatics
Mol File: 10540-29-1.mol
Chemical Properties
White Crystalline Solid
mp 97-98 °C(lit.)
storage temp. 2-8°C
Usage
A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response mo difiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Contact
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Hubei yuan cheng sai chuang technology co., LTD.
Address: 496 zhongshan road of Wuchang district of wuhan city, hubei province,China, wuhan, hubei, China, 430061
Tel: 86-13207152765
Hubei yuan cheng sai chuang technology co., LTD., founded in 2010, the company mainly in chemical synthetic drug substances and drug products, pharmaceutical intermediates, chemical raw materials, chemical antisepsis, flavor spices, food additives and other products r&d, production, management, sales for the integration of large comprehensive high-tech enterprises. Company is located in xiaogan xiaonan district along the border with wuhan east hill office fall river downstream of the lock, close to fall river levee, only 10 minutes drive from 107 national highway, the traffic is very convenient. Factory covers an area of 50 mu, proposed the construction of factory building will be made according to GMP standard, the factory environment is clean and tidy, rational layout, has large and medium-sized production workshop and shop help workshop, and equipped with advanced instruments and equipment quality inspection and research center.