Tamoxifen Citrate - 54965-24-1

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Tamoxifen Citrate

Product name:Tamoxifen Citrate
Molecular Formula: C26H29NO.C6H8O7
Molecular weight: 563.64
CAS NO.: 54965-24-1
Appearance: white crystalline powder
MP: 140-144 oC
Description: Tamoxifen Citrate Tablets, a nonsterodial antiestrogen, are for oral administration and contain 15.2 mg of Tamoxifen Citrate (equivalent to 10 mg of tamoxifen). In addition, each tablet contains as inactive ingredients: carboxymethylcellulose calcium, magnesium stearate, mannitol and starch.
Tamoxifen Citrate is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbezanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, tamoxifen appears to exert its antitumor effects by binding the estrogen receptors. It is also recognized that tamoxifen displays estrogenic like effects on several sites including the endometrium, bone and lipids.
In cytosols derived from human breast adenocarcinomas, tamoxifen competes with estradiol for estrogen receptor protein.

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