Pharmaceutic Machinery

Rutinraw

English
name: Flos sophorae immaturus, Japanese pagodatree flower-bud Synonym:
Meletin, sophoretin Origin: The flower bud of sophora japonica L Plant
morphology: Deciduous tree with height of about 15-25meters Collecting
and processing: Collect the flower bud in summer, drying timely,
removing the branches, stems and impurities Appearance: The shape of
flower bud is oval, with length of 2-6mm, diameter of about 2mm
Odorless, slightly bitter taste Chemical composition: Contains rutin,
saponin and sterol Property and Flavor: Slightly cold in nature, bitter
taste Indications: Cooling blood and hemostasis, purging liver fire, for
the treatment of hemafecia, hemorrhoidal bleeding, blood dysentery,
uterine bleeding, hematemesis, epistaxis, conjunctival hyperemia caused
by hepatopyretic disease, headache and dizziness Dosage: 4 5-9g

Rutin Products

Product name: Rutin

Synonym: Rutoside, Vitamin P, Violaquereitrin

Chemical Name: 

3-{[6-0-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy}-2-(3, 4-dihyroxyphenyl)-5, 7-dihydroxy-4H-1-benzopyran-4-one. 

Molecular Structure:

M. F. & M. W.: C27H30O16; 610.51

Physical
Property: Yellowish- needle - crystal (in water); M. P.: 176-8°C, 23D:
+13.82°C (ethanol), 20D-39.43 °C (pyridine); Solubility: 1g in 7ml of
methanol, 8000ml of water, 200ml of boiling water; UVλ CH3OHmax nm:
258.361; IRνKBr max cm-1: 3400(OH), 1670(C=O), 1620, 1520, 1470(C6H5-). 

Plant
source: Ruta graveolens L., plant essential oil [2]; Sophora japonica
L., main part of fruit [3, 4]; Hypericum aseyron L., full plant;
Berchemia polyphylla Wall, var leioclada Hand. -Mazz. [5]; Mallotus
japonicus Muell. -Arg, leafs [6]; Fagopyrum esculentum Moench seedling. 

Indications: 

1.
Anti-inflammatory action: Apparent suppression of inflammation due to
planted wool when the product is injected into abdominal cavity of rat
[8]. Sodium rutin sulfate has very strong anti-inflammatory action to
edema of rat [9]. 

2. Actions like Vitamin P: Maintain the strength
of blood vessel, reduce its permeability and brittleness; Degreasing
action to liver fatty infiltration, especially together with
glutathione. 

3. Antiviral action: Best suppression to phlyctenular stomatitis virus at product concentration of 200g/ml [10, 11]. 

4.
Inhibition of aldehyde reductase: 95% inhibition at a concentration of
10-5M [12], which facilitates the treatment of diabetic cataract. 

5. Toxicity: Mice, intravenous injection, LD50 at 950mg/kg. 

6.
Clinical use: For the prevention of intracerebral hemorrhage,
hypertension, retinal hemorrhage, purpura and acute hemorrhagic
nephrosonephritis; For treatment of chronic tracheitis with effective
rate at 84.8% and 98%. Its derivative, troxerutin, or Venoruton, is
applied clinically for burn, arthritis, and all kinds of blood vessel
diseases. Commodity drug is available in abroad [14], while the drug has
been successfully developed in domestic. With Effective rate for the
treatment of cerebrovascular diseases is 87.8%; 88% for retinal edema
and hemorrhage

Specification of Rutin (NF11) 

Specification of Rutin (EP8.0) 

Specification of Rutin (DAB10)