Inorganic Chemicals

Veterinarians prescribe potassium or sodium bromide to control seizures in epileptic dogs. Potassium bromide, usually the first choice in treatment, replenishes chloride and accumulates in body fluids over time. If seizures are life-threatening and treatment is needed immediately, veterinarians start a loading dose of bromide higher than they would for milder cases of epilepsy. For non life-threatening epilepsy, the dose is gradually increased to a therapeutic level over three to four months. While bromide poisoning is rare, it can occur in dogs with kidney impairment or those prescribed a high dose.
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Potassium bromide decreases seizure activity by & quot;depressing neuronal activity and excitability,& quot; says Barbara Forney, DVM. The drug is typically well absorbed orally and then excreted by the kidneys. Management of the dose requires measuring the drug level in the dog& acute;s serum regularly to avoid bromide toxicosis, or bromism.