Rutin NF11/EP8/DAB10, China Rutin NF11/EP8/DAB10 Supplier

Rutin NF11/EP8/DAB10 - EHP-130

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RUTIN (Sophora japonica extract)

Rutinraw

English
name: Flos sophorae immaturus, Japanese pagodatree flower-bud Synonym:
Meletin, sophoretin Origin: The flower bud of sophora japonica L Plant
morphology: Deciduous tree with height of about 15-25meters Collecting
and processing: Collect the flower bud in summer, drying timely,
removing the branches, stems and impurities Appearance: The shape of
flower bud is oval, with length of 2-6mm, diameter of about 2mm
Odorless, slightly bitter taste Chemical composition: Contains rutin,
saponin and sterol Property and Flavor: Slightly cold in nature, bitter
taste Indications: Cooling blood and hemostasis, purging liver fire, for
the treatment of hemafecia, hemorrhoidal bleeding, blood dysentery,
uterine bleeding, hematemesis, epistaxis, conjunctival hyperemia caused
by hepatopyretic disease, headache and dizziness Dosage: 4 5-9g

Rutin Products

Product name: Rutin

Synonym: Rutoside, Vitamin P, Violaquereitrin

Chemical Name:

3-{[6-0-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy}-2-(3, 4-dihyroxyphenyl)-5, 7-dihydroxy-4H-1-benzopyran-4-one.

Molecular Structure:

M. F. & M. W.: C27H30O16; 610.51

Physical
Property: Yellowish- needle - crystal (in water); M. P.: 176-8°C, 23D:
+13.82°C (ethanol), 20D-39.43 °C (pyridine); Solubility: 1g in 7ml of
methanol, 8000ml of water, 200ml of boiling water; UVλ CH3OHmax nm:
258.361; IRνKBr max cm-1: 3400(OH), 1670(C=O), 1620, 1520, 1470(C6H5-).

Plant
source: Ruta graveolens L., plant essential oil [2]; Sophora japonica
L., main part of fruit [3, 4]; Hypericum aseyron L., full plant;
Berchemia polyphylla Wall, var leioclada Hand. -Mazz. [5]; Mallotus
japonicus Muell. -Arg, leafs [6]; Fagopyrum esculentum Moench seedling.

Indications:

1.
Anti-inflammatory action: Apparent suppression of inflammation due to
planted wool when the product is injected into abdominal cavity of rat
[8]. Sodium rutin sulfate has very strong anti-inflammatory action to
edema of rat [9].

2. Actions like Vitamin P: Maintain the strength
of blood vessel, reduce its permeability and brittleness; Degreasing
action to liver fatty infiltration, especially together with
glutathione.

3. Antiviral action: Best suppression to phlyctenular stomatitis virus at product concentration of 200g/ml [10, 11].

4.
Inhibition of aldehyde reductase: 95% inhibition at a concentration of
10-5M [12], which facilitates the treatment of diabetic cataract.

5. Toxicity: Mice, intravenous injection, LD50 at 950mg/kg.

6.
Clinical use: For the prevention of intracerebral hemorrhage,
hypertension, retinal hemorrhage, purpura and acute hemorrhagic
nephrosonephritis; For treatment of chronic tracheitis with effective
rate at 84.8% and 98%. Its derivative, troxerutin, or Venoruton, is
applied clinically for burn, arthritis, and all kinds of blood vessel
diseases. Commodity drug is available in abroad [14], while the drug has
been successfully developed in domestic. With Effective rate for the
treatment of cerebrovascular diseases is 87.8%; 88% for retinal edema
and hemorrhage

Specification of Rutin (NF11)

Product Name: Rutin Botanical source: Sophorae Japonica Part of plant used: Flower CAS #: 153-18-4
TEST	NF11	TEST METHOD
Appearance Identification pH Particle size Chlorophyll Red-pigments Quercetin Bluk Density Tapped Density Heavy metals -Arsenic -Mercury -Cadmium -Lead Ash Loss on drying Assay(on dry basis)	Yellow to greenish-yellow powder Must positive 6.0-7.0 95% pass through 60 mesh ≤0.004% ≤0.004% ≤5.0% ≥0.40GM/cc ≥0.60GM/cc ≤10ppm ≤1ppm ≤0.1ppm ≤1ppm ≤3ppm ≤0.5% 5.5%-9.0% 95.0%-102.0%	Visual Infrared Absorption pH Meter US Screen UV UV HPLC CP2010 CP2010 Visual Colorimetry AAS AAS AAS AAS CP2010 120oC UV

Specification of Rutin (EP8.0)

Product Name: Rutin Botanical source: Sophorae Japonica Part of plant used: Flower CAS #: 153-18-4
TEST	EP8.0	TEST METHOD
Appearance Solubility Identification Particle size Residual Solvents Light absorbing impurities Substance Insoluble in methanol Related Substances A: Isoquercetin B. Kaempferol 3-Rutinoside C. Quercetin Other impurity Total impurity Sulphated Ash Water Assay(On dry basis) Heavy metals -Arsenic -Mercury -Cadmium -Lead Bulk Density Tapped Density	Yellow to greenish-yellow, crystalling powder Practically insoluble in water, soluble in methanol, sparingly soluble in ethanol, practically insoluble in methylene chloride, it dissolves in soluble of alkali hydroxides B. CRS absorbance A. UV absorbance C. TLC Examination D. Color reaction with Zn 95% pass through 80 mesh ≤0.2% ≤0.10 between 450 and 800nm ≤3.0% ≤2.0% ≤2.0% ≤2.0% ≤0.1% ≤4.0% ≤0.10% 7.5%-9.5% 95.0%-101.0% ≤10ppm ≤1ppm ≤0.1ppm ≤1ppm ≤3ppm ≥0.30GM/cc ≥0.50GM/cc	Visual Visual CRS TLC UV Visual CP2010 HPGC UV CP2010 HPLC HPLC HPLC HPLC HPLC CP2010 -Karl Fischer Titration Visual Colorimetry AAS AAS AAS AAS CP2010 CP2010

Specification of Rutin (DAB10)

Product Name: Rutin Botanical source: Sophorae Japonica Part of plant used: Flower CAS #: 153-18-4
TEST	DAB10	TEST METHOD
Appearance Melting point Identification(A/B/C) Purity Insoluble Matter -Solution(a) -Solution(b) Particle size Related Substances Isoquercetin Quercetin Kaempferol 3-Rutinoside Bluk Density Tapped Density Heavy metals -Arsenic -Mercury -Cadmium -Lead Ash Loss on drying Assay(on dry basis)	Light greenish yellow powder 210oC melting and decompositon Must positive Must Conforms Should be clarified Should be clarified 95% pass through 80 mesh Must Conforms ≤2.0% ≤2.0% ≤2.0% ≥0.30GM/cc ≥0.50GM/cc ≤10ppm ≤1ppm ≤0.1ppm ≤1ppm ≤3ppm ≤0.10% 5.5%-8.5% 98.0%-102.0%	Visual Infrared Absorption pH Meter US Screen UV UV HPLC CP2010 CP2010 Visual Colorimetry AAS AAS AAS AAS CP2010 120oC UV

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