Bio-technology Products

Creative Biolabs can assist your directed evolution projects by a rich combination of bioinformatics and DNA library synthesis.

The likelihood of success in a directed evolution experiment is directly related to the total library size, as evaluating more mutants increases the chances of finding one with the desired properties. Creative Biolabs synthetic libraries overcome many of the limitations of conventional variant-library construction techniques. De novo gene synthesis enables construction of virtually any gene variation so that your library encodes maximum variability. Supported by CD Genomics assisted sequence design, synthetic libraries achieve thorough representation of desired variants with the specified distribution of nucleotides in areas targeted for partial degeneration or full randomization. The gene synthesis process simultaneously minimizes the introduction of unwanted mutants and erroneous changes to non-mutated portions of your constructs. This approach dramatically reduces the number of variants economizing screening time, reagents, and effort while increasing your chance of success. Because library synthesis is largely automated, we can offer rapid production times so that you can get started quickly. Our rigorous quality control systems include sequencing, statistical sequence analysis, and real-time PCR diversity analysis (control procedures are tailored to individual product lines).