Piperine, China Piperine Supplier

Piperine - STA-13

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Name:Piperine

IUPAC name:1-[5-(1,3-benzodioxol- 5-yl)-1-oxo-2,4-pentadienyl]piperidine

Other names:5-(3,4-methylenedioxyphenyl)-2,4-pentadienoyl-2-piperidine piperoylpiperidine

Molecular formula: C17H19NO3

Molecular weight: 285.34　
CAS No: 94-62-2

Molar mass :285.34 g mol?1

Density: 1.193 g/cm3

Melting point :130 °C, 403 K, 266 °F

Preparation

Piperine is commercially available. If desired, it may be extracted from black pepper using dichloromethane. The amount of piperine varies from 1-2% in long pepper, to 5-9% in the white and the black peppers of commerce. Further, it may be prepared by treating the solvent-free residue from an alcoholic extract of black pepper, with a solution of sodium hydroxide to remove resin (said to contain chavicine, an isomer of piperine) and solution of the washed, insoluble residue in warm alcohol, from which the alkaloid crystallises on cooling.

Biological activity

The pungency caused by capsaicin and piperine is caused by activation of the heat and acidity sensing TRPV ion channel TRPV1 on nociceptors (pain sensing nerve cells).

Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds. Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.

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Changsha Staherb Natural Ingredients Co.,Ltd.

Address: No.186,Lugu Valley Garden Road, High-tech Development Zone, Changsha , Hunan, P.R. China(410205), Changsha, Hunan, China, 410205
Tel: 0086-183-74838656
Changsha Staherb Natural Ingredients Co.,Ltd., a good supplier of professional herb extracts, especially those with high purity and standardized production process. Our company devotes to supply high quality products and services to customers in R&D and production fields of health products, cosmetics, feed additives and biopesticides. With cordial and professional R&D, sales and after sales service groups, Staherb has potent capabilities both in R&D and production. The company persists in high investment on R&D of active ingredients of plants and promotes innovation on demands of customers. Upon constant R&D and tracing of new technologies and new products, Staherb makes effective cooperation with famous research institutes, such as CAS Kunming Institute of Botany, State Key Lab of Hunan Forest Products and Chemical Engineering, Hunan Agricultural University and so on.. Now the main products of Staherb are standardized high purity plant extracts, including Epimedium (10-98%), Eucommia leaf Extract (5-95%) amygdalin (50-98%), Ursolic acid (25-98%),and Corosolic acid (1-98%). In order to meet customers鈥檙esearch needs, our company also provides over 600 plant extracts, most of which are high-purity monomer plant compounds and reference substance. And some products can be supplied with milligram-scale, kilogram-scale or even to ton-scale. In addition, based upon the powerful R&D capability, Staherb can provide both products customization services and R&D outsourcing services according to customers specific requirements, so that to meet their continual innovation needs in the fields of natural productsdiscovery and production.