Pharmaceutical Active Ingredients Pharmaceutical Raw Materials Avanafil CAS 330784-47-9 - 330784-47-9
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Pharmaceutical Active Ingredients Pharmaceutical Raw Materials Avanafil CAS 330784-47-9
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Quick Details:
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# Production Name: Avanafil
# Alias: 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
# CAS No: 330784-47-9
# Einecs No:
# MF: C23H26ClN7O3
# MW: 483.9506
# Purity: 99%min
# Appearance: white powder
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Product Description:
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For most individuals, the recommended starting dose of avanafil is 100 mg per day taken about 30
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minutes before sexual Avanafil activity. Depending on the adequacy of the response or side effects, the
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dose may be increased to 200 mg or decreased to 50 mg a day. Individuals who are taking medications
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that moderately increase Avanafil the blood levels of avanafil should not exceed a total dose of 50 mg in
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24 hours.Avanafil?acts?by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various
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body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other?similar drugs are
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sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast?on set ? ?of ?action
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?compared ?with other PDE5 inhibitors. It is absorbed quickly, reaching a?maximum concentration in about
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30–45 minutes. About two-thirds of the participants were able to?engage in sexual activity within 15
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minutes.
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Specifications :
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Water Content: | 0.5%max | conforms |
Specific Rotation: | 0.5%max | conforms |
Residue on Ignition: | 0.5%max | conforms |
Density: | 1.020-1.035 | 1.03 |
Characteristics: | white powder | Pass |
Solubility: | Almost insoluble in water, soluble in vegetable oil | Conforms |
Specific optical rotation: | +28o～+35o | +33.4o |
Identification: | IR,TLC | Positive |
Heavy Metals: | ＜20PPm | 10PPm |
Assay: | 97.00% | 97.13% |
Related substances: | 3.0%max | ＜3.0% |
Free Acid: | 0.5%max | 0.16% |
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Applications:
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1. ?Avanafil occurs as white crystalline powder, molecular formula C23H26ClN7O3 and molecular weight of
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483.95 and is slightly soluble in ethanol, practically insoluble in water, and soluble in 0.1?mol/L ?
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hydrochloric acid. for oral administration, is supplied as oval, pale yellow tablets containing 50 mg, 100
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mg, or 200 mg avanafil debossed with dosage strengths.
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2. ?Avanafil is a potent, highly selective phosphodiesterase 5 inhibitor, in vitro experiments showed that
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the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other
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phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular
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effects of avanafil should be weaker than .
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3. ?Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on
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blood pressure was significantly weaker than and nitrate drugs with clothes. Moreover, avanafil inhibition
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of phosphodiesterase 6 is very weak, the relevant visual disturbance suppression may the enzyme
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phosphodiesterase 5 inhibitor induced and other.
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Advantages:
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Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
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1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are
allowed to sell.
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2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within
24 hours after receiving the payment Lead time 4 or 7 days.
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3. ?Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
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4. ?Warm after-sale service Any of your question would be solved for the first as soon as possible.
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? Pharmaceutical Raw Materials Avanafil white powder CAS NO 330784-47-9
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Hubei XinRunde Chemical Co., Ltd
Address: Room 2702, #2 Unit, No.2 Buliding, Central Plaza, East and West Lake District, Wuhan, Hubei, China, Wuhan, Hubei, China, 430000
Tel: 86-27-83214668
Hubei XinRunde Chemical co., Ltd is one that production and sales as one of the large high-tech joint-stock enterprises chemical, it is located in the nine provinces of Wuhan, Hubei Province, Tongqu East Lake Technology Development Zone, the traffic is very convenient.
