Palmitoylethanolamide CAS 544-31-0 as Natural Painkiller (jerryzhang001@chembj.com) - 544-31-0

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Palmitoylethanolamide CAS 544-31-0 as Natural Painkiller   (jerryzhang001@chembj.com)

Palmitoylethanolamide CAS 544-31-0 as Natural Painkiller

Quick Detail:
Product Name: Palmitoylethanolamide
Synonyms:
N-(2-HYDROXYETHYL)HEXADECANAMIDE;N-HEXADECANOYLETHANOLAMINE;PEA PALMIDROL;PALMITYLETHANOLAMIDE;PALMITOYLETHANOLAMIDE;PALMITOYLETHANOLAMIDE N-(2-HYDROXYETHYL)HEXADECANAMIDE;n-(2-hydroxyethyl)-hexadecanamid;Palmidrol

CAS: 544-31-0;
MF: C18H37NO2;
EINECS: 208-867-9;
MW: 299.49.

Description:
Palmitoylethanolamide?(PEA) is an endogenous?fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha?(PPAR-alpha).

PEA also has affinity to cannabinoid-like G-coupled receptors?GPR55?and GPR119. PEA cannot strictly be considered a classic?endocannabinoid because it lacks affinity for the cannabinoid receptors?CB1?and?CB2. However, the presence of PEA (and other structurally related?N-acylethanolamines) has been known to enhance anandamide activity by a so-called & quot;entourage effect& quot;.

Several papers have demonstrated that an imbalance of the endocannabinoid system (ECS) and alterations in the levels of PEA occur in acute and chronic inflammation. For instance during beta-amyloid-induced neuroinflammation the deregulation of cannabinoid receptors and its endogenous ligands accompanies the development and progression of disease.

PEA has been shown to have?anti-inflammatory, anti-nociceptive, neuroprotective, and?anticonvulsant?properties.

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Nanjing Bangnuo Biotechnology Co., Ltd.is a comprehensive and high-tech enterprise specializing in pharmaceutical raw materials and its intermediates ,which including raw steroid powder(Testosterone,Boldenone,Nandrolone,Trenbolone,DECA,Anavar/Oxandrolone,NPP,EQ, Winstrol,Dianabol,Nolvadex,Sildenafil citrate,Cialis/Tadalafil),Injection steroid liquid , Peptides( MT-2,GHRP-2,PT-141,CJC-1295),HGH176-191,SARMs(MK-2866,MK-677,LGD-4033,GW-501516,S4),Local anesthetics(Benzocaine,Lidocaine,Tetracaine),GBL,Phenacetin,BB,BA etc. With the era of time, now we have developed as integrating R&D, manufacturing, operating and marketing into an organic whole. We have been serving in this field for over 16 years. Our products achieve the advanced standard of domestic market, many of which conform to the international standard, Kosher Certificate and ISO9001.Our products aimed at global markets , such as United State(USA) , United Kingdom(UK) , Australia , Canada , Spain , France , Germany , Russia , Brasil(Brazil) , Ukraine , South Africa , Norway , Poland , Netherlands(Holland) , Slovakia , Georgia , New Zealand , Sweden etc. Our factory located in China mainland Nanjing City of Jiangsu Province, which covers an area of 20000 square meters with clean environment and nice layout for the produce of pharmaceutical & its intermediates. We own several large-sized, medium-sized workshops and QA and research center with advanced equipments. Our company engaged in gym training , and all of our staff will pursue high quality and perfect brand with untiring efforts, and inherit company spirit on "energy-saving, factual, enterprising and innovative ", follow the company management theory of "lives, services or soul of quality ", with the first-class products and high-quality service to meet market's demands. Main products : Testosterone , Boldenone , Nandrolone , Trenbolone , DECA , Anavar , GHRP-6, MT-2, HGH176-191 , SARMs , GBL , Phenacetin , BB , BA etc.

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