Chemical Auxiliary

Male Sex Health Supplements Generic Priligy Dapoxetine Hydrochloride 129938-20-1 ? ? Quick Detail of Dapoxetine HCl ? Alias: Priligy CAS No: 129938-20-1 MF: C21H23NO. HCl MW: 341.88 Raw Injectable / Oral Dapoxetine / Priligy Medical Male Sex Steroid Hormone CAS 129938-20-1 Purity: 99% Appearance: White powder, odorless, slightly sweet, soluble in water and alcohol. ? General Infomation Of Dapoxetine HCl Product Description: ? Dapoxetine is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin& acute;s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. ? Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse effect (AE) incidence associated with the use of dapoxetine (30?mg and 60?mg) versus placebo, and evaluate the differences in administering 60?mg versus 30?mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that dapoxetine (in the 30?mg and 60?mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for 60?mg versus 30?mg of dapoxetine administration. The most common AEs were mild and tolerable. We conclude that dapoxetine (particularly the 60?mg dosage) may be considered a safe and effective drug for patients with PE. ? Application: ? Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression. Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse. ? To treat premature ejaculation, both psychological and physiological factors need to be managed. From a pharmacological point-of-view, to treat the physiological aspect of premature ejaculation, dapoxetine hydrochloride is one of the first oral drugs to be made available. Psychological treatment may be given concomitantly, as the condition is multifactorial. ? One of the possible adverse effects reported with SSRIs when used to treat depression is delayed ejaculation. This reported adverse effect led to the studies of dapoxetine hydrochloride, using the effect therapeutically. It is thought that serotonin may be involved in the inhibition of ejaculation. By blocking the serotonin reuptake in men suffering from premature ejaculation, the time to ejaculation may be prolonged. ? Initially, dapoxetine hydrochloride is given as a 30 mg tablet one to three hours before sexual intercourse. The dose may be increased by the prescribing doctor to 60 mg, depending on response and tolerance. The tablet should be taken with water and may be taken with or without food, as absorption is not affected by food. ? As with any drug, dapoxetine hydrochloride may cause adverse effects. The most common of these include dizziness, nausea, headache and diarrhea. If any untoward or serious effects are experienced, they should be discussed with the prescribing medical practitioner. Dapoxetine hydrochloride may interact with other drugs. This is important with drugs that may bring about similar adverse effects, such as those causing hypotension, or lowered blood pressure, especially on standing up. Concomitant diseases, such as liver or renal dysfunction and some cardiac diseases, may be a contraindication to using the drug, and the prescribing doctor should be informed of other medications or conditions. ? The drug should not be taken as a chronic medication or as a daily dose. It should only be taken when needed. Dapoxetine hydrochloride should be taken before sexual intercourse is desired and not more than once in a 24 hour period. ? Spefication: ?
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Items of analysis | Specification | Results |
Characteristics | White or almost white crystalline powder | White crystalline powder |
Melting point | 175.0~177.0oC | 176.0oC |
Specific rotatlon | +128°±3(C=1,CH3OH) | +128°±3(C=1,CH3OH) |
Loss on drying | ≤0.5% | 0.32% |
Heavy metals | 0ppm | 0ppm |
Relative substance | Total impurity≤0.1% | 0.07% |
Assay(on dried basis) | ≥99.5% | 99.61% |
Conclusion | It complies to enterprise standard |
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