Pharmaceutical Products

1. Basic Information:
Product Name Levocetirizine Dihydrochloride
Synonym Levocetirizine,Levocetirizine 2HCL,Levocetirizine DIHCL,Levocetirizine HCL,Xyzal,Xuzal,Zilola,2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
CAS 130018-87-0
MF C21H27Cl3N2O3
MW 461.81
Assay 99%
Quality Standards USP/Pharma Grade
Appearance White powder

2. Quick View:
Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the R-enantiomer of the cetirizine racemate. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever.

3. History and formulations:
(1) Levocetirizine was first launched in 2001 by Belgian pharmaceutical company UCB. It is sold under the brand name Xyzal in Australia, Austria, Croatia, Czech Republic, Finland, France, Ireland, Lithuania, Netherlands, Portugal, Romania, Taiwan, Turkey, The Philippines, United States, Serbia, Slovakia, Slovenia, South Africa and UK; Xuzal in Mexico; Xusal in Germany; Xazal in Spain; and Xozal in Greece. In Hungary it is marketed by Richter Gedeon under the Zilola brand name.