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Ledipasvir intermediates - NDHS

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Ledipasvir intermediates

1. (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid
CAS NO: 74761-42-5
M.F: C7H13NO4
M.W：175.18242

2. (6S)-6-[5-[7-[2-(1R,3S,4S)-2-Azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane hydrochloride (1:4)
CAS NO: 1499193-67-7
M.F：C35H32F2N6.4(HCl)
M.W：720.52
：

3. 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone
CAS NO: 1378387-81-5
M.F：C15H8BrClF2O
M.W：357.58

4. (1R,3S,4S)-3-(6-Bromo-1H-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester
CAS NO: 1256387-74-2
M.F：C18H22BrN3O2
M.W：392.29

5. (S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid
CAS NO: 1129634-44-1
M.F：C12H19NO4
M.W：241.28

6. (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt (1:1)
CAS NO: 1441673-92-2
M.F：C12H18NO4.K
M.W：279.37

7. (6S)-6-[5-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane-5-carboxylic acid 1,1-dimethylethyl ester
CAS NO: 1441670-89-8
M.F：C27H26BrF2N3O2
M.W：542.42

8. (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester
CAS NO: 1256387-87-7
M.F：C24H34BN3O4
M.W：439.36

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