Bio-technology Products

Colorectal cancer is a leading cause of illness and death in the world. Fecal occult blood (& quot;FOB& quot;) is a good indicator for monitoring bleeding from the gastrointestinal (GI) system. Since it may take several years for some colon polyps to transform into colorectal cancers, the detection of bleeding colon polyps is an effective way to screen for colorectal cancer at an early stage. The implementation of a procedure to screen for occult blood in fecal samples for adults of 50 years or older has reduced the incidences of colorectal cancer by 20% and mortality by 30%.
Transferrin(TF) is a blood-derived component that may be leaked into gastrointestinal tract and then discharged with the feces in gastrointestinal bleeding diseases. Transferrin is stable in feces and a good marker to detect loss of blood from the upper and lower intestine (gastrointestinal bleeding). This immunochromatographic assay detects human hemoglobin and human transferrin in stool samples simultaneously, will improve the test sensitivity without sacrificing test specificity.
The test uses new homogenous immunochromatographic system with gold particules. It is a ready to use test which only needs a faecal sample dilution with the supplied ready to use dilution buffer. Specificity is ensured by using a monoclonal antibody conjugated with gold particules and directed against specific human hemoglobin or transferrin. The immunochromatographic test is coated with a monoclonal immunoreagent specific for human hemoglobin and transferrin. Liquid sample and gold conjugate both migrate by capillarity and reach the first specific anti-hemoglobin monoclonal reagent. If hemoglobin is present in the sample, it is blocked and immunoreaction appears as a red-pink line. As sample still migrates, it reaches the second specific reagent line against transferrin,? then migrate to the non specific anti-mouse IgG which gives rise to a third red-pink line. This line indicates that the chromatography has been developed