Biochemical

Quick Detail:
Procuct Mame :Dextromethorphan Hydrobromide
Alias: Dextromethorphan Hbr, Dextromethorphan Hydrobromicum, Dextromethorphan Hydrobromide, Romilar
Dextromethorphan Hydrobromide
CAS Number: 125-69-9
Formula: C18H26BrNO
Molecular Weight: 352.3091
Synonyms: Dextromethorphan Hydrobromide; Dextromethorphan HBr
EINECS: 204-750-1
Boiling Point: 427.5 C at 760 mmHg
Flash Point: 212.3 C
Assay: 99% min
Appearance: White crystalline powder
Usage: The central Antitussives mainly inhibit the extension of the brain& acute;s cough center and play
a role, used for treatment of little phlegm cough caused by colds, acute and chronic bronchitis, sore
throat, bronchial asthma, tuberculosis and other upper respiratory tract infections.
Description:
DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.