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Dapoxetine

Alias:(S-(+)-N,N-Dimethyl-a-[2-(naphthalenyloxy)ethyl]benzenemethanamine hydrochloride
CAS:119356-77-3
MF:C21H23NO.HCl
MW:341.88
Density:1.081 g/cm3
FP:132.6°C
BP:454.4C at760mmHg
Vapour pressure:1.91E-08mmHg at 25° C
Refractive Index:1.607
Assay:99% min
Appearance:White to off-white crystalline powder
Storage:Shading, confined preservation
Key words:Dapoxetine 119356-77-3 PE IELT ED male sex enhancer


Application:

Dapoxetine is a white powder substance and water-soluble. Taken 1-3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cm) is reached 1-2 hours after oral administration.
Randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1-3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE.