Pharmaceutical Products

basic info


General description Pharmacological effects Pharmacodynamics Pharmacokinetics Application Synthetic route PrecautionsAdverse reactions Contraindications Chemical Properties Application Production methods
Product Name: Clozapine
Synonyms: 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-;Asaleptin;clorazil;Clozapin;e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(;Iprox;Lepotex;W-801
CAS: 5786-21-0
MF: C18H19ClN4
MW: 326.82
EINECS: 227-313-7
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Dopamine receptor;Miscellaneous;API;Isotope;BENOQUIN;Other APIs
Mol File: 5786-21-0.mol
Clozapine Chemical Properties
mp 182-185°C
storage temp. Store at RT
solubility ethanol: 1 mg/mL
CAS DataBase Reference 5786-21-0(CAS DataBase Reference)
NIST Chemistry Reference Clozapine(5786-21-0)
Safety Information
Hazard Codes Xn,Xi,T,F
Risk Statements 22-36/37/38-68-63-39/23/24/25-23/24/25-11
Safety Statements 26-36/37-45-16-7
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS HP1750000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data 5786-21-0(Hazardous Substances Data)
Clozapine Usage And Synthesis
General description Clozapine appears as pale yellow crystalline powder. It is odorless, tasteless with a molecular weight of 326.83 and a melting point 183 ~ 184 °C. It is soluble in chloroform, ethanol but insoluble in water. It is withdrawn from market because of causing neutropenia in 1976. Later studies have shown that this product has a good efficacy in treating schizophrenia, and thus had re-entered into market in 1989, 1990, in Sweden and the United States, respectively. This product is a non-classical antipsychotic which can selectively block DA receptors of the mesolimbic system but has a small effect on the nigrostriatal DA receptors. It has a relatively weak blocking effect on D2 receptor, but a strong blocking effect on D1 receptors strong while also has some antagonist effect