Cialis Tadalafil Powder Oral Drug Phosphodiesterase Inhibitor For Treating Impotence - 171596-29-5
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Product Name | Tadalafil |
Chemical Name | Cialis |
CAS Number | 171596-29-5 |
EINECS | 200-787-2 |
Molecular Formula | C22H19N3O4 |
Molecular Weight | 389.341 |
Melting Point | 187-189°C |
Purity | 99.5% |
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Description:
CIALIS (tadalafil) is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Tadalafil has the empirical formula C22H19N3O4 representing a molecular weight of 389.41.It is a crystalline solid that is practically insoluble in water and very slightly soluble in ethanol.
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CIALIS is available as almond-shaped tablets for oral administration. Each tablet contains 2.5, 5, 10, or 20 mg of tadalafil and the following inactive ingredients: croscarmellose sodium, hydroxypropyl cellulose, hypromellose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide, and triacetin.
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Mechanism of Action:
Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum.
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The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation.
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CIALIS for Use as Needed for ED:
The efficacy and safety of tadalafil in the treatment of erectile dysfunction has been evaluated in 22 clinical trials of up to 24 weeks duration, involving over 4000 patients. CIALIS, when taken as needed up to once per day, was shown to be effective in improving erectile function in men with erectile dysfunction (ED).
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CIALIS was studied in the general ED population in 7 randomized, multicenter, double-blinded, placebo-controlled, parallel-arm design, primary efficacy and safety studies of 12-weeks duration. Two of these studies were conducted in the United States and 5 were conducted in centers outside the US. Additional efficacy and safety studies were performed in ED patients with diabetes mellitus and in patients who developed ED status post bilateral nerve-sparing radical prostatectomy.
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In these 7 trials, CIALIS was taken as needed, at doses ranging from 2.5 to 20 mg, up to once per day. Patients were free to choose the time interval between dose administration and the time of sexual attempts. Food and alcohol intake were not restricted.
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Side effects:
Cialis (tadalafil) is an oral drug called a phosphodiesterase inhibitor used for treating impotence (erectile dysfunction, or ED). The most common side effects of Cialis are flushing (redness or warmth of the face, neck, or chest); headaches; stomach upset; diarrhea; flu-like symptoms such as stuffy nose, sneezing, or sore throat; memory problems; muscle or back pain; and nausea. Cialis also may cause low blood pressure, blurred vision and changes in color vision, abnormal ejaculation, and priapism.
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The recommended dose of Cialis is 5-20 mg per day taken before sexual activity. The breakdown and elimination of Cialis from the body may be decreased by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir). Therefore, these drugs may increase the levels of Cialis in the blood. Cialis exaggerates the increases in heart rate and lowering of blood pressure caused by nitrates (for example, nitroglycerin, isosorbide dinitrate (Isordil), isosorbide mononitrate (Imdur). Cialis is not approved for use in women and has not been evaluated in women who are breastfeeding.
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