Chloramphenicol, CAS 56-75-7, China Chloramphenicol, CAS 56-75-7 Supplier

Chloramphenicol, CAS 56-75-7 - 56-75-7

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What is Chloramphenicol?
Chloramphenicol is a prototypical broad-spectrum antibiotic. It is a bacteriostatic made of Streptomyces venezuelae by David Gottlieb and became available for clinical application in 1949. It was the first antibiotic to be manufactured synthetically on a large scale.

The pharmacokinetics and action mechanism of Chloramphenicol
Chloramphenicol is a small molecule which is extremely lipid soluble and relatively unbound to protein. It works by inhibiting protein synthesis through preventing protein chain from extending by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation. While chloramphenicol and the macrolide class of antibiotics both interact with ribosomes, chloramphenicol is not a macrolide. It directly interferes with substrate binding, whereas macrolides sterically block the progression of the growing peptide.
The distribution of Chloramphenicol in the body is not uniform. It is metabolized by the liver to chloramphenicol glucuronate, which is inactive, and the majority of the chloramphenicol dose is excreted by the kidneys as the inactive metabolite, chloramphenicol glucuronate. As a result, the highest concentrations are in the liver and kidney, and the lowest concentrations are in the brain and cerebrospinal fluid. When the meninges are not inflamed, the concentration achieved in brain and cerebrospinal fluid is around 30-50%, while the percentage rises to 89% when the meninges are inflamed.
Moreover, chloramphenicol increases the absorption of iron.

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Banff green technologies, inc. Is a technologically innovative company that focuses on chemicals, materials, pharmaceuticals, crop science and environmental technology. The company headquarter is based in shanghai, china. Our research and development team is comprised of a talented and experienced team of phd鈥檚 with strong scientific backgrounds dedicated to our mission. We are also supported by strong infrastructure, which include state of the art lab facilities, two pilot facilities and seven manufacturing sites located in five provinces in china. Our core businesses span over the following areas: r & d, production and sales of fine and specialty chemicals, contract manufacturing services and custom synthesis. Our main products are: fluorinated fine chemicals (mainly diethyl fluoromalonate and dimethyl fluoromalonate), d-p-methyl sulfone phenyl ethyl serinate, florfenicol, d-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-propanediol, and chloramphenicol). Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.