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cutting needle Cannula. Cutting needles Cannula have a barbed edge that enables them to tear larger tissue samples from the pulmonary nodule, allowing for a histologic evaluation (Figure 5). These cutting needles vary in size from 18 to 21 gauge and can be spring-loaded in the form of a biopsy gun, commonly referred to as a core biopsy needle. The spring-loaded cutting needle or biopsy gun is typically only used with nodules > 2 cm because the specimen receptacle of the needle is located 0.5 cm proximal to the needle tip, and the receptacle itself measures at least 1 cm in length. Using a biopsy gun on a subcentimeter nodule introduces the dilemma of not knowing whether the sample was actually obtained from within the nodule as the biopsy gun was fired.