Anti Cancer and Anti Estrogen Steroids Anastrozole Aromatase Inhibitors CAS:120511-73-1 - 120511-73-1
Anti Cancer and Anti Estrogen Steroids Anastrozole Aromatase Inhibitors CAS:120511-73-1 For Sale, Most Competitive Price, Fast Delivery, Custom Service, Wholesale Anti Cancer and Anti Estrogen Steroids Anastrozole Aromatase Inhibitors CAS:120511-73-1, Made in China, High Quality Products!, China cheap prodocuts, china suppliers Supplier, Manufacturer.
Anti estrogen steroids powder Anastrozole/Arimidex for treating breast cancer?cheryl@chembj.com
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Product name | Anastrozole |
Other name | Arimidex |
CAS register number | 120511-73-1 |
Melting Point | 116-118°C |
Molecular formula | C17H19N5 |
Molecular weight | 293.37 |
Molecular structure | N/A |
Assay | 98% |
Appearance | White crystalline powder |
Usage | An aromatase inhibitor. |
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Description:
ARIMIDEX (anastrozole) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor.Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range.
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Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.
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How anastrozole works?
Anastrozole lowers the amount of oestrogen in the body. The female sex hormones oestrogen and progesterone stimulate many breast cancers to grow. Lowering the level of oestrogen can stop or slow the growth of breast cancer cells.
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Anastrozole blocks a process called aromatisation which changes sex hormones called androgens into oestrogen. This happens mainly in the fatty tissues, muscle and the skin and needs a particular enzyme called aromatase.
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Mechanism of Action:
The growth of many cancers of the breast is stimulated or maintained by estrogens.
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In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. The suppression of estrogen biosynthesis in peripheral tissues and in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme.
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Anastrozole is a selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.
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Adjuvant Treatment:
ARIMIDEX is indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
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First-Line Treatment:
ARIMIDEX is indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer.
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Second-Line Treatment:
ARIMIDEX is indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. Patients with ER-negative disease and patients who did not respond to previous tamoxifen therapy rarely responded to ARIMIDEX.
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Dosage and direction:
Follow all instructions of your doctor about treatment and dosing schedule. Do not take more of this medication than it was administered to you. Take once daily.
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Precautions:
Inform your doctor if you are pregnant or breastfeeding, if you have a severe liver disease, history of stroke of blood clot, heart disease, circulation problems, or if you have not yet completed menopause. If you have such conditions you may need adjustment of your dose. Your treatment with Armidex may continue for five years. This medication may impair your ability to high concentration of attention and thinking or reactions: be especially careful while driving or operating machinery.
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Contraindications:
Do not use Armidex in premenopausal women, in pregnant and breastfeeding women, severe kidney disorders, moderate and severe liver diseases, hypersensitivity to Armidex or other components of the drug. Preparations which contain estrogens should not be administered with Armidex as they neutralize its pharmacological effect.
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Side effects:
The most frequent side effects include sings of allergy (hives, skin rash, facial swelling and difficulty breathing) together with sudden headache, confusion, problems with vision, speech, or balance, sudden numbness or weakness, especially on one side of the body, a bone fracture, swollen glands, swelling in your hands or feet. Rare and not so serious adverse reactions may include hot flashes, sore throat, weakness, back pain, bone pain, nausea.
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