6-APB - 6-APB
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6-APB is a triple monoamine reuptake inhibitor with Ki values of 117, 150 and 2698 for NET, DAT and SERT respectively as well as being a potent agonist for the 5-HT2B receptor (Ki 3.7nM).[1] The subjective effects and structure–activity relationship suggest that it is also a releasing agent.
The agonism for 5-HT2B makes it likely that 6-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA.[1] 6-APB has also been claimed to act as an agonist of the 5-HT2C receptor and therefore be useful as an appetite suppressant.[2] However while 6-APB is an agonist at all three 5-HT2 receptor subtypes, its potency at 5-HT2B is significantly higher, and it is actually both more potent and more selective over other serotonin receptors than the reference agonist BW723C86 which is commonly used for research into 5-HT2B receptors.
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