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Odanacatib (MK 0822) is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K (IC50=0.2nM), which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Odanacatib is currently in clinical development for the treatment of postmenopausal osteoporosis.
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