Organic Chemicals

However, the reaction system has a very strong corrosion on the device, produce a large number of waste acid and waste water containing organic compounds, environmental pollution is serious, the cost of governance is high. In addition, the nitrification system often have the problem of poor regioselectivity, poor functional groups tolerance and side effects, particularly unsuitable for the nitration of the acid-sensitive substrates. Therefore, people carried out on a variety of new nitrating agent and catalyst system in-depth research. Recently, transition metal catalyzed aryl halide and pseudohalide nitrification and aryl boronic acids, aromatics carbon - hydrogen bond oxidative nitration has made significant progress.
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As we all know, the transition metal-catalyzed cross-coupling reaction is to build one of the chemical bonds of carbon - carbon and carbon - hetero bond.Therefore, aromatic halides(such as 1-Chloro-2-iodo-4-nitrobenzene) and transition metal-catalyzed coupling reactions pseudohalide nitrification, extensive attentions paid by organic chemists.