1,4,8,11-Tetraazacyclotetradecane - 155148-31-5
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Identification of 155148-31-5
Name:1,4,8,11-Tetraazacyclotetradecane
Molecular Formula:C28H54N8.8ClH
CAS Registry Number:155148-31-5
Synonyms:1,4,8,11-Tetraazacyclotetradecane,1,1& acute;-[1,4-phenylenebis(methylene)]bis-, octahydrochloride (9CI); 1,1& acute;-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride;
Chemical Properties
Molecular Weight:502.78
Density:0.962g/cm3
Highly selective CXCR4 chemokine receptor antagonist (IC 50 values are 0.02 - 0.13 and > 25 μ M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC 50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo .
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