104987-11-3 Tacrolimus Pharmaceutical Intermediates Organ 104987-11-3 White Crystalline Powder - 104987-11-3
104987-11-3 Tacrolimus Pharmaceutical Intermediates Organ 104987-11-3 White Crystalline Powder For Sale, Most Competitive Price, Fast Delivery, Custom Service, Wholesale 104987-11-3 Tacrolimus Pharmaceutical Intermediates Organ 104987-11-3 White Crystalline Powder, Made in China, High Quality Products!, China Steroids, chemical Supplier, Manufacturer.
Tacrolimus Pharmaceutical Intermediates Organ 104987-11-3 White Crystalline Powder
Basic info:
Tacrolimus
Purity: 99%
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Melting Point: 113-115° C
Boiling Point: 871.7 ° C at 760 mmHg
Appearance: White powder
Delivery time: Usually 4-6 working days by air
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Application:
L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
Interactions :
Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
Ulcerative colitis:
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
Dermatological Use:
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is eq
Guangzhou Kafen Biotech Co., Ltd.
Address: No. 128, Hanxing East Rd, Zhongcun, Panyu District,, Guangzhou, GuangDong, China, 511495
Tel: +8618022403273
Guangzhou Kafen Biotech Co., Ltd is a high-tech and professional company founded in 2002, which specialized in developing, manufacturing, distributing steroid hormone powders and intermediates. We have been devoted in R&D, production and marketing steroid hormone and pharmaceutical raw materials.
With advanced production technology and equipment, strong technical force, first-class laboratory and inspection equipment. Kafen has developed into a professional factory manufacturing anabolic steroid powders with several years'efforts and contribution of experienced technicians in different areas. Company affiliated factory has advanced production equipment and plants, perfect quality assurance and control system, whole set of High Pressure Liquid Chromatography/Gas Chromatography/UV Spectrophotometer to conduct effective product analysis and monitoring. Company factory has passed ISO9001 quality system certification and international KOSHER certification.
Now, we continues its high speed development and contributes a lot to its new products' R&D and quality improvement. Under the credibility and win-win principle, kafen biotech will devote to culture innovation to provide excellent products and best service to our customers.
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