Power Distribution Equipment
Description
GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively. GSK1838705A prevents the in vitro proliferation of cell lines derived from solid and hematologic malignancies, including multiple myeloma and Ewing抯 sarcoma, and retards the growth of human tumor xenografts in vivo. Despite the inhibitory effect of GSK1838705A on insulin receptor, minimal effects on glucose homeostasis were obtained at efficacious doses. A single oral dose of GSK1838705A at 0.1 and 0.3 mg/kg led to 35% and 65% prevention of IGF-IR phosphorylation, respectively, whereas doses ≥1 mg/kg led to complete inhibition of ligand-induced IGF-IR phosphorylation.
Sewage Water Pump , Water Pump ,Read More
Yiwu(Yangzhou) Xiyi Electric Equipment Manufacturing and Trade Co.Ltd
anti-twisting steel wire rope,stringing pulley(block),engine/electric powered winch,engine/electric hydraulic pump,cable stand,gin pole,wire grip,come alone clamp and so on
Address: Zonghe Village,Little West Lake street,Yangzhou City,Jiangsu province,China,
Yangzhou, Jiangsu
China, 225000
Tel: 0086-15967906467
Fax: 0086-15967906467
