Pharmaceutical Chemicals
Thiamphenicol CAS 15318-45-3 as broad-spectrum antibiotic chloramphenicol (jerryzhang001@chembj.com)
15318-45-3
Description
Thiamphenicol CAS 15318-45-3 as broad-spectrum antibiotic chloramphenicol
Product Name: Thiamphenicol;
Synonyms: THIAMPHENICOL;methylsulfonyl chloramphenicol;D-THREO-2,2-DICHLORO-N-(BETA-HYDROXY-ALPHA-[HYDROXYMETHYL]-4-[METHYLSULFONYL]PHENETHYL)ACETAMIDE;D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-(METHYL-SULFONYL)PHENETHYL]ACETAMIDE;8065c.b.;acetamide,2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl;dextrosulphenidol;thiocymetin;
CAS: 15318-45-3;
MF: C12H15Cl2NO5S;
MW: 356.22;
EINECS: 239-355-3;
Product Categories: Antibiotics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;CAPITROL;
Melting point: 163-166 °C;
storage temp.: -20°C Freezer, Under Inert Atmosphere;
solubility: ethanol: 50 mg/mL, clear, colorless;
Description:
Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Thiamphenicol is a broad-spectrum antibiotic chloramphenicol, which is more effective to the gram-negative bacteria than the gram-positive bacteria. At room temperature, it is a white to off-white crystalline powder or crystal, which can be quickly and completely absorped by oral adminstration, as well as it is excreted mainly in the prototype from the urine for metabolism.
Clinical application:
Thiamphenicol is clinically applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective.
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